possable hereditary connections?

Why we all seem to carry it all around the waist...

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possable hereditary connections?

Postby shelokay » Fri Jan 23, 2009 5:31 pm

Hi everyone.

I am really looking for experiences people can share with me.
As over the years i have researched pcos i have come across many things. i know there is a very strong link to it being hereditary, and this shows from my nan to my dad down to me. I am diagnosed severe PCOS for the last 12 years.
Also I have discovered that PCOS has only recently been linked with insulin resistance and shows that there is so much more research needed in these fields.

ok fact is insulin resistance produces higher levels of insulin in the blood. that then causes problems with the pituitary gland, and thus secretes incorrect amounts of hormones, resulting in eggs beginging to mature but dont mature enough to be released, then they become foriegn obects, so the body makes them surrounds them by fluid, hence making them a cyst.

right... so the actual effect from the insulin to the pituitary gland doesnt have to be of a major degree.. but the effect on the female reproductive system becomes catistrophic.. as the female repoductive system is so sensitive..

therefore - if i have genetically passed down my condition and the whole insulin resistance to my son then surely having an effect on his pituitary gland could result in one of the other hormones, such as tsh, being effected?

I ask this and ask if anyone else has had the same experience with maybe not just their children but also siblings?

It is just my 2 yr old son has had constipation and muscle cramps and i have been told it is not unusual in children. basically growing pains and i am not feeding him correctly! but i know it is more as i have tried everything to relieve his constipation and it is not working.. so my Dr sent him for blood tests and the tests have come back that he has a slightly higher than normal tsh reading but a normal free t3,t4 reading. so he doesnt have an underactive thyroid altho constipation and muscle cramps are symptons of it. When i discovered the link between tsh and pituitary my alarm bells rang die to my PCOS and the defenant link down my family.

I asked when i went to see the dr about the cramps, and i saw him at the time this 4 month bout of constipation he has, had started, so i asked if we had taken the same blood test then could it have shown a different reading. he doesnt think so but cant say for sure.. but i pushed to be referred to a specialist. which he has done. altho he says insulin resistance is not present in infants.....

As i say all this has so much more research needed.. and so much of this info is new. So i think a link hereditary and to other pituitary hormones as not been made known. (am i making myself clear?) :S

I also remember reading a while back that they thought insulin resistance started in childhood as the pancreas over producing insulin, and as insulin is a poison, the body then builds up a resistance to it.. but they didnt know why the pancreas would start to over produce slightly.. we are not talking high levels of insulin that would cause low blood sugar, just high enough for the body to not like it and build a defence, a resistance.

So i fear the higher tsh level he had, shows he has inherited my insulin condition and he is at the stage where is body is working up a defence and resistance to insulin and maybe if he has tests they can find a cause for him...

to me this makes sense.. mabe i am being ignorant and nieve.
so please anyone else had a simular experience.. or has what i said made a light go on about a child or sibling that you never thought of before.. maybe there pituitary has been effected with the growth hormone or breast milk hormone.... but i think it would be in a mild way, not severe enough for a dr to make a total diagnosis... maybe they had high readings at some point and had to be monitored..

thank you all for reading this.

Postby ameythyst_rune » Tue Mar 03, 2009 6:07 pm

what you've posted is interesting reading. I can't comment on the younger kids in my family because they're miles away but the family link between diabetes and PCOS is very evident in my family. So far my father, paternal grandmother (who is borderline) and maternal uncle have been diagnosed with type 2 diabetes.
I have PCOS and have had blood sugar problems in my memory from my mid teens although I have been tested over and over again and categorically told I don't have diabetes. My male cousin and uncle (paternal side of the family) both developed male pattern hair loss at a very early age (cousin lost his hair by 19, uncle by 20) which is apparently an indication of the male hormonal version of PCOS.

What doctors don't seem to realise is that there is a difference between a global spectrum of blood test results and levels for patients and that of the levels for example of insulin in an individual patient. What is a normal level in one person, can be high in another. I would suggest seeing what the specialist says and going from there. Your son is only two years old though, so knowing what most docs are like they'll probably monitor him as he gets older.

Btw you are right, most endocrine disorder work and work on the pituitary is pretty new. I'm sure if you get on sites like science direct (for academic journals) you might find something to further your case with the specialist.
t.t.c since 04/2007.
got married 12/8/2011
finally confirmed PCOS (2013 after ? since teens) and type 2 diabetes.
Just been confirmed funding for Gastric Bypass Operation - waiting referral appt.
Posts: 173
Joined: Thu Jul 31, 2008 7:55 pm
Location: Gravesend, Kent.

Postby FIREFIGHTER » Tue Mar 03, 2009 11:07 pm

I believe that there's a strong connection of pcos n diabetes my dad has diabetes n he's overweight n my brothers 2 of them r bald from late 20s n but they do have little gals n the rest r boys so I'm worried for them but there's a family history of ashma n excema n hayfever n eye problems n high bp that's it so I'm just worried for all the cute children.

Postby crystalwitch » Wed Mar 04, 2009 10:26 am

I definitely believe PCOS is hereditary, in my family it has come down through my Dad's side of the family. He has diabetes, and it has affected me as PCOS. One of his aunts that we know of, we now believe had PCOS (although I guess nobody knew much about it 'back then'!) as she was overweight and never had any kids despite being married to a catholic!! I don't know much else about his family so I'm not sure if any of his other relatives were diabetic or had PCOS.
It'll stop with my generation anyway, as I'm not having kids and it's looking like my brother won't have any either! :)
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